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On May 10, the Food and Drug Administration (FDA) issued a clarification regarding products compounded from the nucleoside analog GS-441524.

Feline infectious peritonitis (FIP) is caused by mutations of feline coronaviruses. Feline coronaviruses are widespread in nature. There are many strains of coronaviruses, and only a few of them can cause cat feline infectious peritonitis.

Nucleoside analogue GS-441524 is a molecular precursor of a pharmacologically active nucleoside triphosphate molecule.

Although many FIP cats have characteristic CBCs, albumin and globulin levels and A:G, but not every cat will fully match the above parameters, which still need consider combined with age, origin, clinical signs and physical examination.

There is no specific treatment for feline infectious peritonitis. Although recovery from signs has been reported, it is uncommon. Up to 95% of cats with feline infectious peritonitis will die from the disease. In one study, half of the affected cats died within 9 days. However, some cats may live for several months.

The signs of feline infectious peritonitis vary depending on which organs are involved. Many organs, including the liver, kidneys, pancreas, CNS, and eyes, can be affected. The length of time between infection and mutation of the virus and development of signs varies between cats. Affected cats may be alert or depressed. Some eat with a normal or even increased appetite; others refuse to eat. Fever, weight loss, and/or jaundice may be noted.

FIP displays in a “wet” form and a “dry” form. Signs of both forms include fever that doesn’t respond to antibiotics, anorexia, weight loss and lethargy. In addition, the wet form of FIP is most known for the accrual of fluid in the abdominal cavity, the chest cavity, or both. Cats with fluid in the chest experience labored breathing. Cats with fluid in the abdomen show increasing, nonpainful abdominal distension.